Poster Abstract Abstract

(Adults - Diabetes mellitus), #220515386526

CHARACTERISTICS OF COVID-19 PATIENTS WITH HYPERGLYCAEMIC EMERGENCY AND MORTALITY OUTCOMES: SINGLE CENTRE EXPERIENCE IN PAHANG

NURBADRIAH BINTI JASMIAD, HOSPITAL SULTAN HAJI AHMAD SHAH TEMERLOH; SEE CHEE KEONG, HOSPITAL SULTAN HAJI AHMAD SHAH TEMERLOH; YUNG JUNG HAO, HOSPITAL SULTAN HAJI AHMAD SHAH TEMERLOH; NUR LIYANA BINTI ABDUL WAHAB, HOSPITAL SULTAN HAJI AHMAD SHAH TEMERLOH; NURUL ZAIREEN SYAZWANA BINTI ZAINAL, HOSPITAL SULTAN HAJI AHMAD SHAH TEMERLOH

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Introduction

Individuals with diabetes have similar risk in contracting COVID-19 infection compared to without diabetes. However COVID-19 patients with diabetes are at higher risk for severe outcomes and death. The occurrence of hyperglycaemic emergency and diabetes ketoacidosis(DKA) may worsen the outcomes of COVID-19 infection. This study will determine the characteristics of COVID-19 patients admitted with hyperglycaemic emergency and mortality outcomes in Hospital Sultan Haji Ahmad Shah, Temerloh, Pahang.

Methods

All electronic records of COVID-19 patients admitted from March 2021 until March 2022 were reviewed for occurrence of hyperglycaemic emergency. Data regarding demographics, clinical presentation, laboratory investigations and clinical outcomes were collected. Further analysis with patients subcategorised into 2 timeline: March-December 2021 (group 1) and January-March 2022 (group 2) reflecting two surges of COVID-19 admission to the hospital.

Results

24 COVID-19 patients with hyperglycaemic emergency [mean age 56.7(SD 15.6) years, 54.2% female, 79.2% Malay ethnicity, 95.8% Type 2 Diabetes, 54.2% unvaccinated, 70.8% category 5 infection] were analysed. 79.2% of patient had DKA [mean pH 7.16(SD0.12), mean HCO3 10.80(SD3.07), mean glucose at diagnosis 25.3(SD11.0) mmol/L]. Mean length of hospitalization was 11.42(SD7.4) days and mortality rate was 63.2%. 9 DKA cases were detected in group 1 compared to 10 cases during the shorter timeline in group 2. All patients had resolved DKA but majority succumbed later due to complications of COVID-19 infection. Mortality rates in both groups were 66.7%(n=6) and 60%(n=6) respectively.

Conclusion

Despite high occurrence of uncontrolled diabetes during COVID-19 infection in this cohort, only small proportion had hyperglycaemic emergency. In both timeline of hospitalisation surge, COVID-19 patients with concomitant hyperglycaemic emergency had poorer prognosis.

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