Oral Abstract Abstract

(Adults - Thyroid), #220519677329

Prevalence of low BMD and its associated factors in differentiated thyroid cancer patients receiving TSH suppression therapy

Lee Siow Ping, Hospital Melaka; Azraai Bahari Nasruddin, Hospital Putrajaya

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0193551195

Introduction

TSH suppression therapy has been reported to cause low BMD. Osteoporotic fracture is associated with increased morbidity and mortality. Hence, a targeted screening for osteoporosis is important. The aim of this study is to determine the prevalence of low BMD among differentiated thyroid cancer (DTC) patients receiving TSH suppression therapy and its associated factors.

Methods

This was a cross–sectional study done at Hospital Putrajaya. About 98 patients with DTC receiving TSH suppression therapy (mean TSH levels ≤0.5 mIU/L within the past one year) were recruited between August 2020 and March 2021.

Results

The prevalence of low BMD among DTC patients on TSH suppression therapy was 27.6% (osteopenia=22.4%, osteoporosis=4.1%, BMD below the expected range for age=1%). Age was a risk factor of low BMD with the adjusted odds ratio (AOR) of 1.14, 95% confidence interval (CI)=1.032–1.262, p=0.010. In addition, postmenopausal women had a 9–fold higher risk of low BMD compared to men (AOR=8.64, 95% CI=1.436–51.921, p=0.019). Patients with mean TSH <0.1mIU/L had 6–fold increased risk of low BMD compared to those with mean TSH between 0.1mIU/L to 0.49mIU/L (AOR=6.33, 95% CI=1.111–36.072, p=0.038). Lastly, patients who were on calcium supplementation had a 88% lower risk of low BMD compared to those who were not (AOR=0.12, 95% CI=0.025–0.556, p=0.007).

Conclusion

Our study suggests that over a quarter of the DTC patients receiving TSH suppression therapy have low BMD, especially among the older population, postmenopausal women, and patients with mean TSH levels <0.1mIU/L. We should also consider calcium supplementation to prevent bone loss during TSH suppression therapy.

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