Poster Abstract Abstract

(Paediatric), #220529595750


Muntari MI, Paediatric Department, Hospital UiTM Puncak Alam, Selangor; Noordin M, Paediatric Department, Hospital UiTM Puncak Alam, Selangor; Nor NSM, Paediatric Department, Hospital UiTM Puncak Alam, Selangor

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Turner Syndrome (TS) is a genetic disease caused by absence of one X chromosome, and is uncommonly linked with congenital CNS abnormalities. Arnold-Chiari Malformation is rarely associated with TS. Furthermore, there are limited reports available on the outcome of growth hormone (GH) therapy in this group of patients.


We described a 17-year-old girl who was referred to us 3 years ago due to suspicion of TS in view of dysmorphism, short stature and primary amenorrhea.


Her karyotyping confirmed 45,X. Her height at presentation was 132 cm (- 4.98 SDS), weight 45.55 kg (-1.28 SDS), BMI of 26 kg/m2 (+1.72 SDS), with MPH 153cm. She was prepubertal with Tanner staging of A1, B1, PH1. In consistent with primary gonadal failure, her LH and FSH were elevated at 18.1 IU/L and 95 IU/L respectively with low Oestradiol <18.3 pmol/L. Her renal ultrasound was normal. She has no other endocrinopathies. Her other comorbidities include coarctation of aorta, bicuspid aortic valve with severe aortic stenosis, post-balloon valvulotomy and coarctation repair. In view of her short stature, she was planned for GH therapy. Assessments pre-GH therapy revealed an incidental findings of central apnoea from polysomnography with an Apnoea-Hypopnea Index (AHI) of 22.5/H. This has led to MRI brain that revealed cerebellar tonsil descended 7 mm below the foramen magnum, consistent with Arnold-Chiari Type I malformation.


This case highlights the challenge of initiating GH therapy for a patient with Turner Syndrome and Arnold Chiari Type I malformation. Proper counselling with the patient and family is crucial to balance the harm and benefit of GH therapy. The decision to start GH therapy requires multidisciplinary management with close follow-up to monitor any complications and to avoid adverse events.

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