Oral Abstract Abstract

(Adults - Thyroid), #220530830987

The Effects of Low Dose Radioactive Iodine on Ovarian Reserve Among Graves’ Disease Patients

Jin Hui Ho, Endocrinology Unit, Hospital Putrajaya, Wilayah Persekutuan Putrajaya, Malaysia.; Serena Sert Kim Khoo, Endocrinology Unit, Queen Elizabeth Hospital II, Kota Kinabalu, Sabah, Malaysia.; Mohd Noor Nurain, Endocrinology Unit, Hospital Putrajaya, Wilayah Persekutuan Putrajaya, Malaysia.

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High dose radioactive iodine (RAI) has shown to reduce ovarian reserve. We aimed to evaluate the effects of low dose RAI on ovarian reserve among Graves’ disease(GD) patients and factors associated with changes of anti-Müllerian hormone(AMH) level.


50 premenopausal GD women participated in this study, 25 had RAI therapy and 25 continued on anti-thyroid drugs(ATD). Serum follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), thyroid-stimulating hormone(TSH), free thyroxine(FT4), anti-TSH receptor antibody(TRab), anti-thyroid peroxidase antibody(anti-TPO) and 25-hydroxyvitaminD levels were measured at baseline and AMH levels were measured at baseline, 3 and 6 months follow-up.


The mean age of participants was 31.22±5.27years with median thyrotoxicosis duration of 36(68)months. The median dose of RAI was 15(5)mCi. The mean AMH level for RAI-treated group were 22.88±13.20, 20.75±14.31, and 21.57±15.33pmol/L, while the mean AMH level for medical therapy group were 26.36±17.16, 24.27±14.28 and 25.07±16.92pmol/L, respectively at baseline, 3 and 6 months follow-up and both groups were not significantly differed between these time points (p=0.383; p=0.354). The reduction of AMH level were 13.15±30.76% and 2.10±27.08% at 3 months; 5.04±38.66% and 5.13±28.28% at 6 months for RAI and medical therapy group, respectively (p=0.184; p=0.993). Only the age of menarche was negatively correlated (r=-0.436, p=0.029) with percentage of changes in AMH at 3 months.


Low dose RAI has no significant effect on ovarian reserve and age of menarche is negatively correlated with AMH changes at 3 months.

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