Either Abstract

(Adults - Diabetes mellitus), #220531318470

Clinical Characteristics, Glycaemic Control and Hypoglycaemia Events Detected Using CGMS Among Type 1 Diabetes Patients in HTAA.

Ng Yong Siang, Hospital Tengku Ampuan Afzan; Abdullah Shamshir Abd Mokti, Hospital Tengku Ampuan Afzan; Raja Nurazni Raja Azwan, Hospital Tengku Ampuan Afzan; Goh Kian Guan, Hospital Tengku Ampuan Afzan

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Introduction

The incidence of T1D in Asia is approximately 2-5 per 100,000 person-year. Hypoglycaemia is common among patients with T1D. Some might be asymptomatic for hypoglycaemia. CGMS appears to be a useful tool to detect hypoglycaemia events.

Methods

We conducted a retrospective audit of the medical records of 26 patients diagnosed with T1D attending the diabetes clinic at HTAA during the period from 1st January 2021 until 31st December 2021. Demographic data, anthropometric measurement, and biochemical data were collected. The number of events and duration of hypoglycaemia for patients with CGMS data using Flash Libre™ system was analysed. All data were presented in median and interquartile ranges.

Results

26 patients with T1D were analysed. Most of them were Malay. 69.3% were female and the median age was 27 years old (23-35). The age of diagnosis was 19 years old (15-25). HBA1c was suboptimal at 9.65% (8.4-12.2). Total daily dose (TDD) of insulin used was 37.5 units/day (30-44) and 0.68 units/kg/day (0.54-0.77). Among patients with T1D, five subjects had CGMS done. The median number of hypoglycaemia events was 11 (5.5-11.5) in fourteen days and the duration of hypoglycaemia events was 102 minutes (80-183).

Conclusion

In our cohort, the median HBA1c was similar to the national average (10.8%). However, the number of hypoglycaemia discovered via CGMS was high. This could be explained by the high TDD of insulin used. Higher TDD of insulin might have contributed to hypoglycaemia leading to defensive eating which resulted in hyperglycaemia. The study was limited by the number of patients with CGMS due to the acceptance of the patients. CGMS should be recommended to all T1D patients who are known to have a higher risk of hypoglycaemia.

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