Oral Abstract Abstract
(Adults - Obesity), #220531798593
APPLYING FUNDAMENTAL HOMEOSTASIS THEORY TO OBESITY MANAGEMENT: A CHEMIST’S AND BIOCHEMIST’S PERSPECTIVES ABOUT TOCOTRIENOLS
Hew Nam Fong, HELP University
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Obesity is a disease having very close relationships with diabetes and metabolic syndrome which encompasses some common health conditions such as high blood pressure, high blood glucose and cholesterol levels, they are also correlated to high risks of developing various non-communicable diseases including cardiovascular diseases and stroke. Many metabolic diseases and syndromes manifest common symptoms and expected results from the same root causes, despite advancement in knowledge and healthcare systems, precise modus operandi are not yet established to resolve the escalating overweight and obesity prevalence. Instead, misconceptions of mass-energy balance, fraudulent calculations of basal metabolic rate (BMR) and daily energy requirements (DER) have deterred the efforts in tackling the worldwide obesity problems.
Individual case studies have been initiated by calculation of BMR values using new predictive equations based on BMR=10m+5h. The subjects followed a strict nutritional management plan and changes in lifestyle.
Satisfactory reduction of bodyweight have been achieved within 2-3 months.
Tocotrienols have been reported to be beneficial against obesity, but how it works is still unsolved from the chemistry perspective of vitamin E, a major reason is lack of understanding of the scientific fundamentals related to the development of obesity and its nutritional resolutions.
Fundamental homeostasis theory is a novel theory newly constructed to explain the diverse activities of vitamin E, its concepts is now extended to investigate the etiology of obesity. Particularly, some homeostasis concepts in terms of fundamental chemical and biochemical species will be addressed, such as oxidants and reductants either from exogenous or endogenous sources. The antioxidant activity of tocotrienols and their radicals is substantiated by electron spin resonance studies. The potential roles of vitamin E in anti-inflammation such as occurs in COVID-19 infections, long covid and post-vaccination syndrome is also an anticipation target for discussion.