Poster Abstract Abstract

(Adults - Diabetes mellitus), #220531946761

PREVALENCE AND ASSOCIATED FACTOR OF METABOLIC BONE DISEASE IN MALE TYPE 2 DIABETES MELLITUS

Hanis Rabeah Kamaruzaman, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh , Selangor, Malaysia; Sharifah Faradila Wan Muhamad Hatta, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh , Selangor, Malaysia; Rohana Abd Ghani, Department of Internal Medicine, Faculty of Medicine, Universiti Teknologi MARA, 47000, Sungai Buloh , Selangor, Malaysia

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Introduction

Osteoporosis is recognized as a disease among the postmenopausal women and elderly. Studies have shown that patients with T2DM are at risk of fractures despite having a normal or high BMD. Fractures amongst male T2DM patients have become more prevalent. However, data on these two areas are still lacking. Our aims is to determine the prevalence and associated factors of metabolic bone disease i.e. osteopenia and osteoporosis in males with T2DM.

Methods

Single center, cross-sectional study in male patients T2DM (n=150) above the age of 50 years, on regular follow up at Hospital UiTM from December 2021 until May 2021. Demographic data, biochemical profile were obtained from all the participants. Dual Energy X-ray Absorptiometry (DEXA) was performed and bone densitometry (BMD) was obtained from the lumbar spine (L1-L4) and femoral neck.

Results

Mean age was 64+/-7.2 years. The prevalence of osteoporosis and osteopenia within the study cohort was 4% (6 cases) and 15.3% (23 cases) respectively. The metabolic bone disease group had numerically higher median age, lower eGFR and lower urine albumin creatinine ratio, albeit no statistical significance. Multiple linear regression analysis showed a correlation between hip BMD with BMI and alkaline phosphatase, whereby, a 1kg/m2 increase in BMI increased the hip BMD by 0.008 (CI 0.003-0.012, p=0.001) and 1U/L increase in ALP will reduce the hip BMD by 0.001 (CI -0.002-0.000, p+0.006). Meanwhile other associated factors including age, smoking, eGFR, HbA1C, and UACR showed no significant correlation with metabolic bone disease.

Conclusion

This study showed that the prevalence of osteoporosis and osteopenia amongst male with T2DM is low at 4% and 15.3% respectively. BMI and serum ALP are significant predictor of BMD level for male with T2DM.

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